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| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | RNF7 rabbit polyclonal antibody |
Gene Name: | RING-box protein 2 |
Synonyms: | Rbx2, RING finger protein 7, Sensitive to apoptosis gene protein, Rnf7, Rbx2, Sag |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse RNF7 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Uniprot ID: | Q9UBF6, Q9WTZ1 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 500-1: 3000 | colon, embryonic mouse, heart, lung, testis |
Background
The RNF7 is probable a component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.
Images
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Immunohistochemistry of paraffin embedded human colon using RNF7 (GB111234) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse testis using RNF7 (GB111234) at dilution of 1:1000 (300x lens) |
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Immunohistochemistry of paraffin embedded rat testis using RNF7 (GB111234) at dilution of 1:1000 (400x lens) |
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Immunofluorescence of paraffin embedded mouse embryonic mouse using RNF7 (GB111234) at dilution of 1:2000 (400x lens) |
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Immunofluorescence of paraffin embedded mouse heart using RNF7 (GB111234) at dilution of 1:2000 (400x lens) |
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Immunofluorescence of paraffin embedded rat lung using RNF7 (GB111234) at dilution of 1:2000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
