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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: |
RUNX2 rabbit polyclonal |
| Gene Name: |
Runt-related transcription factor 2 |
|
Synonyms: |
AML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD, OSF-2, OSF2, PEA2aA, PEBP2aA, runt related transcription factor 2 |
| Immunogen: | KLH conjugated Synthetic peptide corresponding to Human RUNX2. |
| Isotype: | IgG |
| Purity: | Affinity purification |
|
Predicted MW. |
57 kDa |
|
Observed MW. |
57 kDa |
| Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1:500-1:2000 | heart, testis, cartilage |
Background
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.
Images
 |
Western blot analysis of RUNX2 (GB13264) at dilution of 1:1000. Lane 1: PC-3 cell lysate Lane 2: HL-60 cell lysate Lane 3: HCT116 cell lysate Lane 4: Mouse heart tissue lysate Lane 5: Mouse testis tissue lysate Lane 6: Mouse cartilage tissue lysate Lane 7: Rat heart tissue lysate Lane 8: Rat testis tissue lysate Lane 9: Rat cartilage tissue lysate |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
