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Anti-S100 beta Mouse mAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Protein S100-B |
Synonyms: | S100B, NEF, S100, S100-B, S100beta,S100 calcium binding protein B, S100β |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse S100B |
Uniprot ID: | P50114 |
Isotype: | IgG1,κ |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 1000-1: 2000 | brain, glioma |
Background
S100B is glial-specific and is expressed primarily by astrocytes, but not all astrocytes express S100B. It has been shown that S100B is only expressed by a subtype of mature astrocytes that ensheath blood vessels and by NG2-expressing cells.This protein may function in neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. In the developing CNS, it acts as a neurotrophic factor and neuronal survival protein. In the adult organism. it is usually elevated due to nervous system damage, which makes it a potential clinical marker.
Images
| Immunohistochemistry of paraffin embedded human glioma using S100B (GB12359) at dilution of 1: 1000 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse brain using S100B (GB12359) at dilution of 1: 1000 (400x lens) |
| Immunohistochemistry of paraffin embedded rat brain using S100B (GB12359) at dilution of 1: 1000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
