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Anti-SART3 Rabbit pAb (100 μl)
| Reactivity: | M |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Squamous cell carcinoma antigen recognized by T-cells 3 |
Synonyms: | DSAP1, hSART 3, KIAA0156, P100, p110, p110(nrb), RP11 13G14, SART 3, SART3, TIP110 |
Immunogen: | Recombinant protein corresponding to Mouse SART3 |
Uniprot ID: | Q9JLI8 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Product Usage Information
IHC/IF | Mouse | 1: 1000-1: 2000 | kidney, testis |
Background
U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation. Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites. May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly.
Images
| Immunohistochemistry analysis of paraffin embedded mouse kidney using SART3 (GB114236) at dilution of 1: 1600 |
| Immunohistochemistry analysis of paraffin embedded mouse testis using SART3 (GB114236) at dilution of 1: 1600 |
| Immunofluorescence analysis of paraffin embedded mouse testis using SART3 (GB114236) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
