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| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SAV1 rabbit polyclonal antibody |
Gene Name: | Protein salvador homolog 1 |
Synonyms: | 45 kDa WW domain protein, mWW45, Sav1, Ww45, Wwp3, hWW45 |
Immunogen: | Recombinant protein corresponding to Mouse SAV1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Uniprot ID: | Q8VEB2 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 200-1: 1400 | testis |
Background
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.
Images
 | Immunohistochemistry of paraffin embedded mouse testis using sav1 (GB112439) at dilution of 1:200 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat testis using sav1 (GB112439) at dilution of 1:200 (300x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
