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| Reactivity: | H,M & H |
| Applications: | WB & IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SDHA rabbit polyclonal |
Gene Name: | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial |
Synonyms: | FP, SDH2, SDHA, SDHF, Flavoprotein subunit of complex II, PGL5, CMD1GG |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse SDHA |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Mitochondrion |
Predicted MW. | 73 kDa |
Observed MW. | 73 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse | 1: 700-1: 1400 | kidney, liver |
IHC | Human | 1: 1200-1: 2400 | colon cancer, liver cancer, kidney cancer |
Background
SDHA, also named as SDH2, SDHF and Fp, belongs to the FAD-dependent oxidoreductase 2 family and FRD/SDH subfamily. SDHA is the flavoprotein subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDHA has 3 isoforms with the molecular mass of 73, 67 and 57 kDa, and the N-terminal (~5 kDa) can be removed in mature form. It can be detected a band of 68 kDa in cutaneous melanoma. SDHA may act as a tumor suppressor.
Images
| Western blot analysis of SDHA (GB113278) at dilution of 1: 1400 |
| Western blot analysis of SDHA (GB113278) at dilution of 1: 1400 |
| Immunohistochemistry analysis of paraffin-embedded human colon cancer using SDHA (GB113278) at dilution of 1: 2400 |
| Immunohistochemistry analysis of paraffin-embedded human liver cancer using SDHA (GB113278) at dilution of 1: 2400 |
| Immunohistochemistry analysis of paraffin-embedded human kidney using SDHA (GB113278) at dilution of 1: 2400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
