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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SGK3 rabbit polyclonal antibody |
Gene Name: | Serine/threonine-protein kinase Sgk3 |
Synonyms: | Cytokine-independent survival kinase, SGK2, Serum/glucocorticoid-regulated kinase 3, Sgkl, Serum/glucocorticoid-regulated kinase-like, Serine/threonine protein kinase Sgk3, Cisk |
Immunogen: | Recombinant protein corresponding to Mouse SGK3 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 57 kDa |
Observed MW. | 57 kDa |
Uniprot ID: | Q96BR1, Q9ERE3, Q8R4V0 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500- 1: 1000 | pancreas, liver |
Background
Serine/threonine-protein kinase Sgk3 (SGK3), belongs to the Ser/Thr protein kinase family of proteins. The serum- and glucocorticoid-regulated kinase proteins are closely related to the Akt protein family. SGK1, a homolog of SGK3, activates ion channels, in particular potassium (K+) channels. SGK2 and SGK3 have been found to also be involved in this activation process, making all three of these proteins important regulators for cell proliferation, epithelial transport and neuromuscular excitability. SGK3 acts as a mediator of IL-3 dependent survival signals in the cell. It localizes to the early endosome and in vesicle-like structures. SGK3 is a widely expressed protein, but it is primarily detected in kidney, liver, pancreas, brain and heart. Phosphorylation of SGK3 at residue Ser 486 leads to an increase in SGK3 activation.
Images
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Western blot analysis of sgk3 (GB11983) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
