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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SHP2 rabbit polyclonal antibody |
Gene Name: | Tyrosine-protein phosphatase non-receptor type 11 |
Synonyms: | Protein-tyrosine phosphatase SYP, SH-PTP2, SHP2, Ptpn11 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse SHP2 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 68 kDa |
Observed MW. | 72 kDa |
Uniprot ID: | Q06124, P35235, P41499 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | ovary |
Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
Images
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Western blot analysis of PTPN11 (GB111075) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
