Your shopping cart is empty!
| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SIRT1 rabbit polyclonal |
Gene Name: | NAD-dependent protein deacetylase sirtuin-1 |
Synonyms: | SIRT1,SIR2L1,SIR2,hSIR2,SIR2alpha, Sirtuin 1 |
Immunogen: | Recombinant protein corresponding to Mouse SIRT1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus,Cytoplasm |
Uniprot ID: | Q923E4 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 300-1: 700 | testis,brain,heart |
IF | Mouse, Rat | 1: 1000-1: 2000 | ovary, spleen, small intestine, testis |
Background
Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by theSIRT1 gene.Sirtuin 1 is downregulated in cells that have high insulin resistance and inducing its expression increases insulin sensitivity, suggesting the molecule is associated with improving insulin sensitivity. Furthermore, SIRT1 was shown to de-acetylate and affect the activity of both members of the PGC1-alpha/ERR-alpha complex, which are essential metabolic regulatory transcription factors.
Images
 |
Immunohistochemistry analysis of paraffin-embedded mouse testis using SIRT1 (GB11512) at dilution of 1:500. |
 |
Immunohistochemistry analysis of paraffin-embedded mouse brain using SIRT1 (GB11512) at dilution of 1:500. |
 |
Immunohistochemistry analysis of paraffin-embedded mouse heart using SIRT1 (GB11512) at dilution of 1:500. |
 |
Immunohistochemistry analysis of paraffin-embedded mouse ovary using SIRT1 (GB11512) at dilution of 1:2000. |
 |
Immunohistochemistry analysis of paraffin-embedded mouse spleen using SIRT1 (GB11512) at dilution of 1:1000. |
 |
Immunohistochemistry analysis of paraffin-embedded mouse small intestinet using SIRT1 (GB11512) at dilution of 1:1000. |
 |
Immunohistochemistry analysis of paraffin-embedded rat testis using SIRT1 (GB11512) at dilution of 1:1000. |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
