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Anti-SIRT2 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SIRT2 rabbit polyclonal antibody |
Gene Name: | NAD-dependent protein deacetylase sirtuin-2 |
Synonyms: | Regulatory protein SIR2 homolog 2, SIR2-like protein 2, mSIR2L2, Sir2l2, Sirt2 |
Immunogen: | Recombinant protein corresponding to Mouse SIRT2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Cytoplasm, Nucleus |
Predicted MW. | 43 kDa |
Observed MW. | 43 kDa |
Uniprot ID: | Q8IXJ6, Q8VDQ8, Q5RJQ4 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | kidney, placenta |
IHC/IF | Mouse, Rat | 1: 1000-1: 2000 | brain |
Background
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.
Images
Western blot analysis of Sir2 (GB112450) at dilution of 1: 500 | |
| Immunohistochemistry of paraffin embedded mouse brain using Sir2 (GB112450) at dilution of 1: 1000 (400x lens) |
| Immunohistochemistry of paraffin embedded rat brain using Sir2 (GB112450) at dilution of 1: 1000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
