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Anti-SLC7A5/LAT1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Large neutral amino acids transporter small subunit 1 |
Synonyms: | 4F2 LC, 4F2 light chain, 4F2LC, CD98 light chain, CD98LC, D16S469E, E16, hLAT1, Integral membrane protein E16, CD98, TA1, LAT1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse SLC7A5/LAT1 |
Uniprot ID: | Q9Z127 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 56 kDa / 37 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 1000-1: 1500 | liver, brain, lung |
Background
The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan. Functions as an amino acid exchanger. May play a role in the transport of L-DOPA across the blood-brain barrier (Probable). May act as the major transporter of tyrosine in fibroblasts. May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier. Can mediate the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane. When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation.
Images
| Western blot analysis of SLC7A5 (GB114871) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
