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| Reactivity: | M & M |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Zinc finger protein SNAI2 |
Synonyms: | Protein snail homolog 2, SLUG, SLUGH, SLUGH1, SNAI2, snail homolog 2 (Drosophila), WS2D |
Immunogen: | Recombinant protein corresponding to Human slug |
Uniprot ID: | O43623 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Predicted MW. / Observed MW. | 30 kDa / 30 kDa |
Product Usage Information
WB | Mouse | 1: 300-1: 600 | heart, brain |
IHC/IF | Mouse | 1: 1000-1: 2000 | skin, testis |
Background
SNAI2 belongs to the Snail family of zinc finger transcription factors, which shares an evolutionarily conserved role in mesoderm formation in vertebrates and invertebrates. It tiggers epithelial-mesenchymal transitions and has a crucial role in developmental processes. Also it is a transcriptional reperssor in mediating RAF-induced expression of TJ protein, occludin(OCLN) and subsequent oncogenic transformation of epithelial cells.
Images
| Western blot analysis of SLUG (GB115172) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded mouse testis using slug (GB115172) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded mouse skin using slug (GB115172) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
