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Anti-SQSTM1/P62 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SQSTM1 rabbit polyclonal |
Gene Name: | Sequestosome-1 |
Synonyms: | SQSTM1, A170, OSIL, PDB3, ZIP3, p60, p62, p62B, FTDALS3, Sequestosome 1, NADGP, DMRV |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse SQSTM1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Late endosome, Lysosome, |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human | 1: 500-1: 1000 | gallbladder |
IF | Human | 1: 500-1: 1000 | gallbladder |
Background
Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family . Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery . Involved in midbody ring degradation . May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity).
Images
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Immunohistochemistry analysis of paraffin-embedded human gallbladder using SQSTM1 (GB11239) at dilution of 1: 500 |
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Immunohistochemistry analysis of paraffin-embedded human gallbladder using SQSTM1 (GB11239) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
