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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | SLIT-ROBO Rho GTPase-activating protein 2C |
Synonyms: | SRGAP2C, SRGAP2P1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human SRG2 |
Uniprot ID: | P0DJJ0 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 53 kDa / 37 kDa |
Product Usage Information
WB | Human | 1: 800-1: 1500 | PC-3, SiHa, A549 |
Background
Human-specific protein that acts as a key modifier of cortical connectivity in the human brain. Acts by inhibiting the functions of ancestral paralog SRGAP2/SRGAP2A, a postsynaptic protein that regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons. SRGAP2C is unstable but is able to heterodimerize with SRGAP2/SRGAP2A, thereby reducing SRGAP2/SRGAP2A levels through proteasome-dependent degradation.
Images
| Western blot analysis of SRG2 (GB115021) at dilution of 1: 80 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
