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Anti-STAT2 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Signal transducer and activator of transcription 2 |
Synonyms: | ISGF 3, P113, STAT113, STAT2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse STAT2 |
Uniprot ID: | Q9WVL2 |
Isotype: | lgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm Nucleus |
Predicted MW. / Observed MW. | 105 kDa / 113 kDa |
Product Usage Information
WB | Human | 1: 200-1: 400 | A431, K-562, HeLa |
Background
Signal transducer and activator of transcription that mediates signaling by type I interferons. Following type I IFN binding to cell surface receptors, Jak kinases are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In addition, has also a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs. Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively.
Images
| Western blot analysis of STAT2 (GB115564) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
