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Anti-STAT6 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | STAT6 rabbit polyclonal antibody |
Gene Name: | Signal transducer and activator of transcription 6 |
Synonyms: | IL-4 Stat, STAT6, Interleukin 4 Induced, Interleukin 4 Induced Transcription Factor IL4 STAT, STAT interleukin4 induced, D12S1644, 12S1644 |
Immunogen: | Recombinant protein corresponding to Mouse STAT6 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 94 kDa |
Observed MW. | 100-110 kDa |
Uniprot ID: | P42226 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse | 1: 500-1: 1000 | THP-1, Jurkat, A20, NIH/3T3, Raw264.7 |
Background
STAT6 is a member of the Janus family tyrosine kinases (Jak)/ STAT signal transduction pathway and mediates cytokine signaling by IL 4 and IL-13. STAT6 has been found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL-4. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT6 is critically involved in Th2 and Th9 immune response. Loss of STAT6 impairs IL-4 mediated functions including Th2 helper T cell differentiation, expression of cell surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL-4 mediated proliferation.
Images
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Western blot analysis of STAT6 (GB111381) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
