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Anti-SYNPO2L Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H,M |
| Applications: | WB & ICC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Synaptopodin 2-like protein |
Synonyms: | Synpo2l, synaptopodin 2 like |
Immunogen: | Recombinant protein corresponding to Mouse SYNPO2L |
Uniprot ID: | Q8BWB1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 103 kDa / 70 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 1000-1: 2000 | heart |
ICC/IF | Human, Mouse | 1: 50-1: 200 | HeLa, NIH-3T3 |
Background
SYNPO2L was initially identified as a novel heart-enriched gene that encodes a cytoskeletal protein highly expressed in the Z-disc of heart and skeletal muscle, associates with actin and interacts with a-actinin. It is a member of the synaptopodin family, sharing greatest homology with Synaptopodin 2. Recent studies have shown that SYNPO2L, while primarily localized to the sarcomere, can also translocate to the nucleus. A knockdown of SYNPO2L in zebrafish resulted in aberrant cardiac and skeletal muscle development and function, suggesting that it is a critical component of the sarcomere and plays an important role in muscle development.
Images
 | Western blot analysis of SYNPO2L (GB112974) at dilution of 1: 1000 |
| Immunocytochemistry analysis of 4% paraformaldehyde-fixed HeLa cells using SYNPO2L(GB112974) at dilution of 1: 50-1: 200 |
| Immunocytochemistry analysis of 4% paraformaldehyde-fixed NIH-3T3 cells using SYNPO2L(GB112974) at dilution of 1: 50-1: 200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
