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Anti-Smoothened Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Smoothened rabbit polyclonal antibody |
Gene Name: | Smoothened homolog |
Synonyms: | Smo, SMO, FZD11, Gx, SMOH, Smoothened, frizzled class receptor, CRJS |
Immunogen: | Recombinant protein corresponding to Mouse Smoothened |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 87 kDa |
Observed MW. | 87 kDa |
Uniprot ID: | P56726, P97698 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | brain, cerebral cortex, cerebellum, hippocampus |
Background
Smoothened is a protein that in humans is encoded by the SMO gene. Smoothened is a Class Frizzled (Class F) G protein-coupled receptor that is a component of the hedgehog signaling pathway and is conserved from flies to humans. It is the molecular target of the natural teratogen cyclopamine. It also is the target of Vismodegib, the first hedgehog pathway inhibitor to be approved by the U.S. Food and Drug Administration (FDA).
Images
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Western blot analysis of SMO (GB11670) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
