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Anti-Sprouty 4/Spry-4 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Spry-4 rabbit polyclonal antibody |
Gene Name: | Protein sprouty homolog 4 |
Synonyms: | Sprouty homolog 4 (Drosophila), HH17, Sprouty homolog 4, SPRY4, sprouty RTK signaling antagonist 4 |
Immunogen: | Recombinant protein corresponding to Mouse Spry-4 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 33 kDa |
Observed MW. | 35 kDa |
Uniprot ID: | Q9WTP2 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | liver, kidney, brain |
Background
This gene encodes a member of a family of cysteine- and proline-rich proteins，also named as Protein sprouty homolog 4, which contains one SPR (sprouty) domain and belongs to the sprouty family. SPRY4 Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Activity of this protein probably impairs the formation of active GTP-RAS. SPRY4 has a cellular function to regulate the actin cytoskeleton, independent of its inhibitory activity on the Ras/MAP kinase signalling. SPRY4, SPRY1, SPRY2, SPRY3 are central and complex regulators of the receptor tyrosine kinase (RTK) signalling pathway.Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants.
Images
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Western blot analysis of SPRY4 (GB11980) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
