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| Reactivity: | H,M,R & M,R & M,R |
| Applications: | WB & IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TAK1 rabbit polyclonal |
Gene Name: | Mitogen-activated protein kinase kinase kinase 7 |
Synonyms: | MAP3K7, MEKK7, TAK1, TGF1a, mitogen-activated protein kinase kinase kinase 7, FMD2, CSCF, MAPKKK7, M3K7 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse TAK1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Membrane |
Predicted MW. | 64 kDa |
Observed MW. | 75 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | spleen, lung, uterus |
IHC | Mouse, Rat | 1: 500-1: 1000 | brain, cerebral infarction |
IF | Mouse, Rat | 1: 250-1: 500 | brain, cerebral infarction |
Background
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), also known as TAK1, is an enzyme which belongs to a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. TAK1 is a central regulator of cell death and is activated through a diverse set of intra- and extracellular stimuli. TAK1 regulates cell survival not solely through NF-κB but also through NF-κB-independent pathways.
Images
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Western blot analysis of TAK1 (GB11701) at dilution of 1: 1000 Lane 1: HeLa cell lysate Lane 2: A549 cell lysate Lane 3: 293T cell lysate Lane 4: Mouse spleen tissue lysate Lane 5: Mouse lung tissue lysate Lane 6: Mouse uterus tissue lysate Lane 7: Rat spleen tissue lysate Lane 8: Rat lung tissue lysate Lane 9: Rat uterus tissue lysate |
| Immunohistochemistry analysis of paraffin-embedded Rat cerebral infarction using TAK1 (GB11701) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded mouse brain using TAK1 (GB11701) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
