Your shopping cart is empty!
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TCF7 rabbit polyclonal antibody |
Gene Name: | Transcription factor 7 |
Synonyms: | TCF-7, T-cell-specific transcription factor 1, T-cell factor 1, TCF-1, Tcf7, Tcf-1, Tcf1 |
Immunogen: | Recombinant protein corresponding to Mouse TCF7 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: | Q00417 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 600-1: 1200 | kidney, thymus |
Background
TCF7 (transcriptional factor 7) is a transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ and CD8+ immature thymocytes. Isoforms for TCF7 lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. TCF7 binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. It may also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3, and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
Images
|
|
Immunohistochemistry of paraffin embedded mouse thymus using TCF7 (GB111378) at dilution of 1:600 (400x lens) |
|
|
Immunohistochemistry of paraffin embedded rat kidney using TCF7 (GB111378) at dilution of 1:600 (400x lens) |
| Immunohistochemistry of paraffin embedded rat thymus using TCF7 (GB111378) at dilution of 1:600 (400x lens) |
| Immunofluorescence of paraffin embedded rat kidney using TCF7 (GB111378) at dilution of 1:600 (400x lens) |
|
|
Immunofluorescence of paraffin embedded rat thymus using TCF7 (GB111378) at dilution of 1:600 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
