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| Reactivity: | M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TGDS rabbit polyclonal |
Gene Name: | dTDP-D-glucose 4,6-dehydratase |
Synonyms: | Tgds, SDR2E1, TDP glucose 4,6 dehydratase, TDPGD |
Immunogen: | Recombinant protein corresponding to Mouse TGDS |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Predicted MW. | 41 kDa |
Observed MW. | 48 kDa |
Uniprot ID: |
Applications
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 1000-1: 2000 | liver, kidney |
IHC/IF | Mouse, Rat | 1: 3000-1: 6000 | bladder |
Background
The protein encoded by this gene is a member of the short-chain dehydrogenases/reductases (SDR) superfamily, and is thought to contain a nicotinamide adenine dinucleotide (NAD) binding domain. This large SDR family of enzymes is involved in the metabolism of a variety of compounds, including prostaglandins, retinoids, lipids, steroid hormones, and xenobiotics. Mutations in this gene have been associated with Catel-Manzke syndrome, which is characterized by Pierre Robin sequence, and radial deviation of the index finger due to the presence of an accessory bone between the index finger and its proximal phalanx. Pierre Robin sequence is defined by an undersized jaw, backwards displacement of the tongue base that causes an obstruction of the airways, and can also be associated with a cleft palate.
Images
| Western blot analysis of TGDS (GB112984) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded mouse bladder using TGDS (GB112984) at dilution of 1: 1500 |
| Immunohistochemistry analysis of paraffin embedded rat bladder using TGDS (GB112984) at dilution of 1: 1500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
