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Anti-TIMP2 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Metalloproteinase inhibitor 2 |
Synonyms: | TIMP2, CSC-21K, DDC8, TIMP metallopeptidase inhibitor 2, CSC21K, Tissue Inhibitor of Metalloproteinase 2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human TIMP2 |
Uniprot ID: | P16035 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted |
Predicted MW. / Observed MW. | 24 kDa / 24 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 500-1: 1000 | kidney, lung, placenta, pancreas |
IHC/IF | Mouse, Rat | 1: 300-1: 800 | kidney, lung |
ICC/IF | Human, Mouse, Rat | 1: 100-1: 400 | NIH-3T3 |
Background
TIMP2 encoded by Timp2 gene are natural inhibitors of the matrix metalloproteinases (MMP), a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, it has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells, which may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
Images
| Western blot analysis of TIMP2 (GB112670) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded rat lung using TIMP2 (GB112670) at dilution of 1: 300 |
| Immunohistochemistry analysis of paraffin embedded rat kidney using TIMP2 (GB112670) at dilution of 1: 300 |
| Immunocytochemistry analysis of 4% paraformaldehyde-fixed NIH-3T3 cells using TIMP2(GB112670) at dilution of 1:100-1:400 |
| Immunocytochemistry analysis of 4% paraformaldehyde-fixed HeLa cells using TIMP2(GB112670) at dilution of 1:100-1:400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
