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| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TLE 1 rabbit polyclonal antibody |
Gene Name: | Transducin-like enhancer protein 1 |
Synonyms: | Tle1, TLE1, ESG, ESG1, GRG1, Transducin like enhancer of split 1, TLE family member 1, Transcriptional corepressor |
Immunogen: | Recombinant protein corresponding to Mouse TLE 1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 500-1: 2000 | colon, corpus striatum, hippocampus, lung, testis |
Background
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Images
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Immunohistochemistry of paraffin embedded mouse lung using groucho (GB11897) at dilution of 1:2000 (300x lens) |
 | Immunohistochemistry of paraffin embedded rat corpus striatum using groucho (GB11897) at dilution of 1:2000 (200x lens) |
 | Immunofluorescence of paraffin embedded mouse colon using groucho (GB11897) at dilution of 1:1000 (300x lens) |
 | Immunofluorescence of paraffin embedded mouse lung using groucho (GB11897) at dilution of 1:1000 (300x lens) |
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Immunofluorescence of paraffin embedded mouse testis using groucho (GB11897) at dilution of 1:1000 (350x lens) |
 |
Immunofluorescence of paraffin embedded rat hippocampus using groucho (GB11897) at dilution of 1:1000 (350x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
