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| Reactivity: | H,M & H,M |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TLR2 rabbit polyclonal |
Gene Name: | Toll-like receptor 2 |
Synonyms: | TLR2, CD282, TIL4, toll like receptor 2, Toll/interleukin receptor like protein 4, TIL4 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse TLR2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Membrane |
Uniprot ID: | O60603, Q9QUN7 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human, Mouse | 1: 500-1: 1000 | ovarian cancer, appendix, liver, lung |
IF | Human, Mouse | 1: 500-1: 1000 | tonsil, cervical cancer |
Background
TLR2 is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities, while the various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-κB. In the intestine, TLR2 regulates the expression of CYP1A1, which is a key enzyme in detoxication of carcinogenic polycyclic aromatic hydrocarbons such as benzo(a)pyrene.
Images
| Immunohistochemistry analysis of paraffin-embedded human ovarian cancer using TLR2 (GB113378) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded mouse liver with LPS treated for 6h using TLR2 (GB113378) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded mouse lung with LPS treated for 12h using TLR2 (GB113378) at dilution of 1: 1000 |
| Immunofluorescent analysis of paraformaldehyde-fixed human cervical cancer using TLR2 (GB113378) at dilution of 1: 1000 |
| Immunofluorescent analysis of paraformaldehyde-fixed human tonsil using TLR2 (GB113378) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
