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Anti-TLS/FUS Rabbit pAb (100 μl)
| Reactivity: | M |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | FUS rabbit polyclonal antibody |
Gene Name: | RNA-binding protein FUS |
Synonyms: | Protein pigpen, Fus, 75 kDa DNA pairing protein, ALS6, FUS CHOP, FUS1, POMp75, Fusion (involved in t(12;16) in malignant liposarcoma), hnRNP P2, Fusion gene in myxoid liposarcoma, Heterogeneous nuclear ribonucleoprotein P2, Oncogene TLS |
Immunogen: | Recombinant protein corresponding to Mouse FUS |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: | P56959 |
Applications
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse | 1: 800-1: 2000 | brain, pancreas, Skeletal muscle |
Background
FUS (also named TLS and POMp75) belongs to the RRM TET family. FUS may play a role in the maintenance of genomic integrity; it binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. FUS is also an RNA-binding protein, and its links to neurodegenerative disease proffer the intriguing possibility that altered RNA metabolism or RNA processing may underlie or contribute to neuron degeneration. FUS may be a cause of angiomatoid fibrous histiocytoma (AFH) and is implicated in certain forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementias (FTDs) such as frontotemporal lobar dementia with ubiquitin inclusions (FTLD-U).
Images
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Immunofluorescence of paraffin embedded mouse brain using FUS (GB111365) at dilution of 1:1000 (400x lens) |
| Immunofluorescence of paraffin embedded mouse pancreas using FUS (GB111365) at dilution of 1:1000 (400x lens) |
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Immunofluorescence of paraffin embedded mouse Skeletal muscle using FUS (GB111365) at dilution of 1:1000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
