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Anti-TMEM100 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Transmembrane protein 100 |
Synonyms: | TMEM100, transmembrane protein 100 |
Immunogen: | Recombinant protein corresponding to Mouse TMEM100 |
Uniprot ID: | Q9CQG9 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 15 kDa / 18 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 100-1: 300 | pancreas, colon, kidney |
Background
Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10 . Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons . Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex .
Images
| Western blot analysis of TMEM100 (GB114244) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
