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Anti-TMEM147 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Transmembrane protein 147 |
Synonyms: | MGC1936, NIFIE14 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse TMEM147 |
Uniprot ID: | Q9CQG6 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Endoplasmic reticulum membrane, Cell membrane |
Product Usage Information
IHC/IF | Mouse, Rat | 1: 800-1: 2400 | liver, lung, spleen |
Background
Component of a ribosome-associated endoplasmic reticulum (ER) translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. Together with SEC61 and TMCO1, forms the lipid-filled cavity at the center of the translocon where TMEM147 may insert hydrophobic segments of mutli-pass membrane proteins from the lumen into de central membrane cavity in a process gated by SEC61, and TMCO1 may insert hydrophobic segments of nascent chains from the cytosol into the cavity. Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane.
Images
| Immunohistochemistry analysis of paraffin embedded rat liver using TMEM147 (GB115306) at dilution of 1:800 |
| Immunohistochemistry analysis of paraffin embedded mouse lung using TMEM147 (GB115306) at dilution of 1:800 |
| Immunohistochemistry analysis of paraffin embedded rat spleen using TMEM147 (GB115306) at dilution of 1:800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
