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Anti-TOP3B Rabbit pAb (100 μl)
| Reactivity: | R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TOP3B rabbit polyclonal antibody |
Gene Name: | DNA topoisomerase 3-beta-1 |
Synonyms: | DNA topoisomerase III beta-1, Top3b, Top3b1, Topo III beta, Topoisomerase III beta |
Immunogen: | Recombinant protein corresponding to Mouse TOP3B |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 97 kDa |
Observed MW. | 97 kDa |
Uniprot ID: | Q9Z321 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Rat | 1: 800-1: 1500 | testis |
Background
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants.
Images
 | Western blot analysis of TOP3B (GB112677) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
