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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TRAF2 rabbit polyclonal antibody |
Gene Name: | TNF receptor-associated factor 2 |
Synonyms: | Traf2, TRAF2, MGC:45012, TRAP, TRAP3, TNF receptor associated factor 2, RNF117 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse TRAF2 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 56 kDa |
Observed MW. | 53 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | ovary, testis |
Background
Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain.
Images
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Western blot analysis of TRAF2 (GB11891) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
