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| Reactivity: | M,R & M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TRAF3 rabbit polyclonal |
Gene Name: | TNF receptor-associated factor 3 |
Synonyms: | TRAF3, Traf3, CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1, TNF receptor associated factor 3, RNF118 |
Immunogen: | Recombinant protein corresponding to Mouse TRAF3 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 1000-1: 3000 | hepatitis, spleen |
IF | Mouse, Rat | 1: 500-1: 1000 | hepatitis, spleen |
Background
TNF receptor-associated factor is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) super family. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1.
Images
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Immunohistochemistry analysis of paraffin-embedded mouse spleen using TRAF3 (GB11722) at dilution of 1: 1500 |
| Immunohistochemistry analysis of paraffin-embedded mouse hepatitis using TRAF3 (GB11722) at dilution of 1: 1500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
