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Recombinant Anti-TSG101 Mouse mAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Tumor susceptibility gene 101 protein |
Synonyms: | TSG10, TSG101, tumor susceptibility gene 101, VPS23, tumor susceptibility 101 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human TSG101 |
Uniprot ID: | Q61187 |
Isotype: | lgG1 |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 44 kDa / 46 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 1000-1: 3000 | heart, brain |
Background
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (By similarity).
Images
| WB analysis of TSG101 (GB15618). Sample: Protein treated by RIPA Lysis Buffer (G2002). Blocking buffer: 3% Nonfat dry milk (GC310001) in TBST, RT, 1h. Primary antibody: 1: 1000, 4°C overnight. Secondary antibody: HRP Goat Anti-Mouse lgG (GB23301), 1: 3000, RT, 1h. |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
