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Anti-TTF1 (Thyroid transcription factor 1) Mouse mAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Homeobox protein Nkx-2.1 |
Synonyms: | Homeobox protein NK-2 homolog A,Thyroid nuclear factor 1,Thyroid transcription factor 1 (TTF-1),NKX2-1,NKX2A, TITF1, TTF1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human TTF-1 |
Uniprot ID: | P43699 |
Isotype: | IgG1,κ |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 500-1: 1000 | lung adenocarcinoma, lung, thyroid gland |
Background
Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1
Images
| Immunohistochemistry analysis of paraffin-embedded human lung adenocarcinoma using TTF-1 (GB122168) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded human lung using TTF-1 (GB122168) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded mouse lung using TTF-1 (GB122168) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded rat lung using TTF-1 (GB122168) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded rat thyroid gland using TTF-1 (GB122168) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human lung using TTF-1 (GB122168) at dilution of 1: 3000 |
| Immunohistochemistry analysis of paraffin embedded human non-small cell lung cancer using TTF-1 (GB122168) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human non-small cell lung cancer using TTF-1 (GB122168) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
