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Anti-TTK/Mps1 Rabbit pAb (100 μl)
| Reactivity: | H & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Dual specificity protein kinase TTK |
Synonyms: | Phosphotyrosine picked threonine-protein kinase, PYT, TTK, MPS1, MPS1L1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human TTK |
Uniprot ID: | P33981 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Predicted MW. / Observed MW. | 97 kDa / 97 kDa |
Applications
WB | Human | 1: 500-1: 1000 | HeLa, MCF7, K562, Jurkat |
IHC/IF | Human | 1: 750-1: 1500 | breast, colon cancer, colon |
Background
Mps1 family of kinases colocalizes with mitotic checkpoint proteins in kinetochores and/or spindle pole bodies/centrosomes. TTK has been shown to be a cell cycle-regulated kinase displaying maximum activity during M phase. Its kinase activity is required for proper chromosome segregation during mitosis through its involvements in microtubule-chromosome attachment error correction and the mitotic checkpoint.
Images
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Western blot analysis of TTK-H (GB111371) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin embedded human esophagus cancer using TTK-H (GB111371) at dilution of 1: 750 |
| Immunohistochemistry analysis of paraffin embedded human colon using TTK-H (GB111371) at dilution of 1: 750 |
| Immunohistochemistry analysis of paraffin embedded human colon cancer using TTK-H (GB111371) at dilution of 1: 750 |
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Immunohistochemistry analysis of paraffin embedded human breast using TTK-H (GB111371) at dilution of 1: 750 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
