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Anti-TrkB Rabbit pAb (100 μl)
| Reactivity: | R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | BDNF/NT-3 growth factors receptor |
Synonyms: | NTRK2, GP145-TrkB, TRKB, trk-B, neurotrophic receptor tyrosine kinase 2, OBHD |
Immunogen: | Recombinant protein corresponding to Mouse TrkB |
Uniprot ID: | P15209 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Product Usage Information
IHC/IF | Human, Mouse, Rat | 1: 500-1: 4000 | brain, spinal marrow |
Background
Tropomyosin receptor kinase B is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations. The neurotrophins that activate TrkB are: BDNF (Brain Derived Neurotrophic Factor), neurotrophin-4 (NT-4), andneurotrophin-3 (NT-3). As such, TrkB mediates the multiple effects of these neurotrophic factors, which includes neuronal differentiation and survival. Research has shown that activation of the TrkB receptor can lead to down regulation of the KCC2 chloride transporter in cells of the CNS.
Images
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Immunohistochemistry analysis of paraffin embedded human stomach using TrkB (GB11295-2) at dilution of 1: 500 |
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Immunohistochemistry analysis of paraffin embedded human brain using TrkB (GB11295-2) at dilution of 1: 500 |
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Immunohistochemistry analysis of paraffin embedded mouse spinal cord using TrkB (GB11295-2) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
