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Anti-UGT1A1 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | UDP-glucuronosyltransferase 1A1 |
Synonyms: | GNT1, HUG BR1, UDPGT, UDPGT 1 1, UGT 1A, UGT1, UGT1 01, UGT1*1, UGT1.1, UGT1A, UGT1A1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse UGT1A1 |
Uniprot ID: | Q63886 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Endoplasmic reticulum membrane |
Product Usage Information
IHC/IF | Human | 1: 300-1: 900 | civer cancer, colon cancer |
Background
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol. Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates. Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II. Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan.
Images
| Immunohistochemistry analysis of paraffin embedded human civer cancer using UGT1A1 (GB114838) at dilution of 1: 300 |
| Immunohistochemistry analysis of paraffin embedded human colon cancer using UGT1A1 (GB114838) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
