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Anti-UPF3A Rabbit pAb (100 μl)
| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Regulator of nonsense transcripts 3A |
Synonyms: | hUpf3, HUPF3A, RENT3A, UPF3, UPF3A |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human UPF3A |
Uniprot ID: | Q9H1J1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 55 kDa / 55 kDa |
Product Usage Information
WB | Mouse | 1: 500-1: 1000 | uterine |
Background
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation.
Images
| Western blot analysis of UPF3A (GB115408) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
