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Anti-USP15 Rabbit pAb (100 μl)
| Reactivity: | H & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Ubiquitin carboxyl-terminal hydrolase 15 |
Synonyms: | Deubiquitinating enzyme 15, KIAA0529, Ubiquitin thiolesterase 15, Unph 2, UNPH4, USP15 |
Immunogen: | Recombinant protein corresponding to Mouse USP15 |
Uniprot ID: | Q8R5H1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus, Mitochondrion |
Predicted MW. / Observed MW. | 112 kDa / 112 kDa |
Product Usage Information
WB | Human | 1: 300-1: 500 | LO2, HeLa |
IHC/IF | Human, Mouse, Rat | 1: 800-1: 2400 | colon, stomach, kidney |
Background
Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes.
Images
| Western blot analysis of USP15 (GB114564) at dilution of 1: 500 |
| Immunohistochemistry analysis of paraffin embedded human colon using USP15 (GB114564) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin embedded human kidney using USP15 (GB114564) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin embedded mouse stomach using USP15 (GB114564) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin embedded rat stomach using USP15 (GB114564) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
