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| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | NEDD4-like E3 ubiquitin-protein ligase WWP1 |
Synonyms: | AIP5, DKFZp434D2111, hSDRP1, Tiul1, WW domain containing protein 1, WWP1 |
Immunogen: | Recombinant protein corresponding to Mouse WWP1 |
Uniprot ID: | Q8BZZ3 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 105 kDa / 105 kDa |
Product Usage Information
WB | Mouse | 1: 2000-1: 3000 | liver |
Background
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF (By similarity). Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7.
Images
| Western blot analysis of WWP1 (GB115415) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
