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| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | XIAP rabbit polyclonal antibody |
Gene Name: | E3 ubiquitin-protein ligase XIAP |
Synonyms: | Baculoviral IAP repeat-containing protein 4, IAP-like protein, API3, BIRC4, IAP3, XIAP, ILP, hILP, Inhibitor of apoptosis protein 3, IAP-3, hIAP3, X-linked IAP |
Immunogen: | Recombinant protein corresponding to Mouse XIAP |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 57 kDa |
Observed MW. | 57 kDa |
Uniprot ID: | P98170, Q60989 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse | 1: 500-1: 1000 | MCF-7, HT-29, Jurkat, Raji, PC-12, HepG2 |
Background
XIAP, also named as API3, BIRC4 and IAP3, belongs to the IAP family. It has E3 ubiquitin-protein ligase activity. It mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. XIAP is an inhibitor of caspase-3, -7 and -9. It mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B. XIAP is an apoptotic suppressor. It is ubiquitinated and degraded by the proteasome in apoptotic cells.
Images
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Western blot analysis of XIAP (GB111208) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
