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Anti-alpha 1 Antitrypsin Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Alpha-1-antitrypsin |
Synonyms: | AAT, Alpha-1 protease inhibitor 2, Alpha-1-antiproteinase, Serine protease inhibitor 1-2, Serine protease inhibitor A1b, Serpin A1b, Serpina1b, Aat2, Dom2, Spi1-2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human SERPINA1 |
Uniprot ID: | P01009 |
Isotype: | lgG |
Purity: | Affinity purification |
Subcellular location: | Secreted |
Product Usage Information
IHC/IF | Human, Mouse, Rat | 1: 300-1: 900 | liver, kidney, lung |
Background
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.; [Short peptide from AAT]: Reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).
Images
| Immunohistochemistry analysis of paraffin embedded human colon using alpha 1 Antitrypsin (GB115592) at dilution of 1:300 |
| Immunohistochemistry analysis of paraffin embedded human liver cancer using alpha 1 Antitrypsin (GB115592) at dilution of 1:300 |
| Immunohistochemistry analysis of paraffin embedded human lung cancer using alpha 1 Antitrypsin (GB115592) at dilution of 1:300 |
| Immunohistochemistry analysis of paraffin embedded mouse kidney using alpha 1 Antitrypsin (GB115592) at dilution of 1:300 |
| Immunohistochemistry analysis of paraffin embedded mouse liver using alpha 1 Antitrypsin (GB115592) at dilution of 1:300 |
| Immunohistochemistry analysis of paraffin embedded mouse lung using alpha 1 Antitrypsin (GB115592) at dilution of 1:300 |
| Immunohistochemistry analysis of paraffin embedded rat kidney using alpha 1 Antitrypsin (GB115592) at dilution of 1:300 |
| Immunohistochemistry analysis of paraffin embedded rat spleen using alpha 1 Antitrypsin (GB115592) at dilution of 1:300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
