Your shopping cart is empty!
Anti-cIAP2 Rabbit pAb (100 μl)
| Reactivity: | M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | cIAP2 rabbit polyclonal antibody |
Gene Name: | Baculoviral IAP repeat-containing protein 3 |
Synonyms: | Cellular inhibitor of apoptosis 2, C-IAP2, Birc3, Inhibitor of apoptosis protein 1, mIAP1, RING-type E3 ubiquitin transferase BIRC3 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse cIAP2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Predicted MW. | 67 kDa |
Observed MW. | 67 kDa |
Uniprot ID: | O08863, Q5XIW4 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 500-1: 1000 | thymus, testis, lymph node |
IHC/IF | Mouse, Rat | 1: 750-1: 3000 | lung, lymph node, spleen, testis |
Background
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase dependent and caspase independent manner.
Images
 |
Western blot analysis of BIRC3 (GB111051) at dilution of 1: 500 |
 | Immunohistochemistry of paraffin embedded mouse lung using BIRC3 (GB111051) at dilution of 1: 1800 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse lymph node using BIRC3 (GB111051) at dilution of 1: 1800 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse spleen using BIRC3 (GB111051) at dilution of 1: 1800 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse testis using BIRC3 (GB111051) at dilution of 1: 1800 (400x lens) |
 |
Immunofluorescence of paraffin embedded mouse lung using BIRC3 (GB111051) at dilution of 1: 1000 (400x lens) |
 |
Immunofluorescence of paraffin embedded mouse lymph node using BIRC3 (GB111051) at dilution of 1: 1000 (400x lens) |
 |
Immunofluorescence of paraffin embedded mouse spleen using BIRC3 (GB111051) at dilution of 1: 1000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
