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Anti-kynurenine 3-monooxygenase Rabbit pAb (100 μl)
| Reactivity: | M,R & H,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | KMO rabbit polyclonal antibody |
Gene Name: | Kynurenine 3-monooxygenase |
Synonyms: | Kynurenine 3-hydroxylase, KMO |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse KMO |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Predicted MW. | 55 kDa |
Observed MW. | 55 kDa |
Uniprot ID: | O15229, Q91WN4, O88867 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 500-1: 1000 | stomach, heart, brain, cartilage |
IHC/IF | Human, Rat | 1: 1000-1: 6000 | colon, esophagus, liver cancer, lung |
Background
KMO(Kynurenine 3-monooxygenase) is an NADPH-dependent flavin monooxygenase, catalysing the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
Images
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Western blot analysis of KMO (GB111295) at dilution of 1: 500 |
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Immunohistochemistry of paraffin embedded human esophagus using KMO (GB111295) at dilution of 1: 900 (400x lens) |
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Immunohistochemistry of paraffin embedded human liver cancer using KMO (GB111295) at dilution of 1: 900 (400x lens) |
| Immunofluorescence of paraffin embedded human colon using KMO (GB111295) at dilution of 1: 1800 (400x lens) |
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Immunofluorescence of paraffin embedded rat lung using KMO (GB111295) at dilution of 1: 1800 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
