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Anti-mSin3A Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | mSin3A rabbit polyclonal |
Gene Name: | Paired amphipathic helix protein Sin3a |
Synonyms: | Histone deacetylase complex subunit Sin3a, Transcriptional corepressor Sin3a, Kiaa4126 |
Immunogen: | Recombinant protein corresponding to Mouse mSin3A |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: | Q60520, D3ZBP2 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 100-1: 200 | colon, kidney, heart, testicle, ovary |
IF | Mouse, Rat | 1: 100-1: 200 | colon, kidney, heart, testicle, ovary |
Background
The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. And It acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation.
Images
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Immunohistochemistry analysis of paraffin-embedded mouse colon using mSin3A (GB11968) at dilution of 1: 100 |
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Immunohistochemistry analysis of paraffin-embedded mouse kidney using mSin3A (GB11968) at dilution of 1: 100 |
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Immunohistochemistry analysis of paraffin-embedded mouse heart using mSin3A (GB11968) at dilution of 1: 100 |
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Immunohistochemistry analysis of paraffin-embedded rat testis using mSin3A (GB11968) at dilution of 1: 100 |
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Immunohistochemistry analysis of paraffin-embedded rat ovary using mSin3A (GB11968) at dilution of 1: 100 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
