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Anti-p40-DeltaNp63 Mouse mAb (100 μl)
| Reactivity: | H & H |
| Applications: | WB & IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Tumor protein 63 |
Synonyms: | AIS, B(p51A), B(p51B), CUSP, EEC3, KET, LMS, NBP, OFC8, p40, p51, p53CP, p63, p73H, p73L, RHS, SHFM4, TP53CP, TP53L, TP63, TP73L, tumor protein p63, Tumor protein p73 like |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human P40 |
Uniprot ID: | Q9H3D4 |
Isotype: | IgG1,κ |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Predicted MW. / Observed MW. | 76 kDa / 76 kDa |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human | 1: 500-1: 1000 | A431 |
IHC/IF | Human | 1: 500-1: 1000 | esophageal cancer, skin |
Background
TP63, also named KET, P63, P73H, P73L and TP73L, belongs to the p53 family. It is a homologue of the tumor suppressor p53 and p73 genes. It is involved in malignancy acquisition and maintenance of cells. Unlike p53, the p63 gene encodes multiple isotypes with remarkably divergent abilities to transactivate p53 reporter genes and induce apoptosis. TP63 acts as a sequence specific DNA binding transcriptional activator or repressor. TP63 has 12 isoforms with MW 40kd(P40), 50kd(P60),63kd(P63) and 73kd(P73L). It is Nuclear stain.
Images
| Western blot analysis of P40 (GB122169) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded human esophageal cancer using P40 (GB122169) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded human skin using P40 (GB122169) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human esophageal cancer using p40 - DeltaNp63 (GB122169) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human non-small cell lung cancer using p40 - DeltaNp63 (GB122169) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
