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| Reactivity: | H & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Cellular tumor antigen p53 |
Synonyms: | TP53, BCC7, LFS1, P53, TRP53, tumor protein p53 |
Immunogen: | Recombinant protein corresponding to Human p53 |
Uniprot ID: | P04637 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Endoplasmic reticulum, Mitochondrion |
Predicted MW. / Observed MW. | 44 kDa / 55 kDa |
Product Usage Information
WB | Human | 1: 1000-1: 2000 | liver cancer, stomach cancer |
IHC/IF | Human | 1: 500-1: 3000 | ovarian cancer |
Background
Tumor protein p53, also known as p53, cellular tumor antigen p53 , phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), which encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, sense cence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome.
Images
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Western blot analysis of P53 (GB11626) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin embedded human ovarian cancer using P53 (GB11626) at dilution of 1: 1600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
