Your shopping cart is empty!
Anti-p95 NBS1 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | p95 NBS1 rabbit polyclonal antibody |
Gene Name: | Nibrin |
Synonyms: | Nbn, NBN, AT-V1, AT-V2, ATV, NBS, NBS1, P95, nibrin |
Immunogen: | Recombinant protein corresponding to Mouse NBS1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: | Q9R207, Q9JIL9 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 500-1: 2500 | heart, kidney, lung, testis |
Background
Nibrin is a protein associated with the repair of double strand breaks (DSBs) which pose serious damage to a genome. It is a 754 amino acid protein identified as a member of the NBS1/hMre11/RAD50(N/M/R, more commonly referred to as MRN) double strand DNA break repair complex. This complex recognizes DNA damage and rapidly relocates to DSB sites and forms nuclear foci. It also has a role in regulation of N/M/R (MRN) protein complex activity which includes end-processing of both physiological and mutagenic DNA double strand breaks (DSBs).
Images
 | Immunohistochemistry of paraffin embedded mouse kidney using NBS1 (GB11794) at dilution of 1:2500 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse testis using NBS1 (GB11794) at dilution of 1:2500 (400x lens) |
 |
Immunohistochemistry of paraffin embedded rat kidney using NBS1 (GB11794) at dilution of 1:2500 (400x lens) |
 |
Immunofluorescence of paraffin embedded mouse lung using NBS1 (GB11794) at dilution of 1:1000 (400x lens) |
 |
Immunofluorescence of paraffin embedded mouse testis using NBS1 (GB11794) at dilution of 1:1000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
