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| Reactivity: | M,R & M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | BLNK rabbit polyclonal |
Gene Name: | B-cell linker protein |
Synonyms: | Blnk, AGM4, BASH, BLNK-S, LY57, SLP-65, SLP65, Bca, B-cell linker |
Immunogen: | Recombinant protein corresponding to Mouse BLNK |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Membrane |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 3000-1: 5000 | spleen |
IF | Mouse, Rat | 1: 1500-1: 2500 | spleen |
Background
The function of BLNK was first illustrated in BLNK deficient DT40 cells, a chicken B-cell line, which exhibited an abrogated intracellular calcium mobilisation response and impaired activation of MAP kinases p38, JNK, and to a lesser degree ERK upon B-cell receptor (BCR) activation as compared to wild type DT40 cells. In knockout mice, BLNK deficiency results in a partial block in B-cell development, and in humans BLNK deficiency results in a much more profound block in B-cell development. Linker or adaptor proteins provide mechanisms by which receptors can amplify and regulate downstream effector proteins. The B-cell linker protein is essential for normal B-cell development.
Images
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Immunohistochemistry analysis of paraffin-embedded mouse spleen using BLNK (GB11734) at dilution of 1: 3000 |
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Immunohistochemistry analysis of paraffin-embedded mouse spleen using BLNK (GB11734) at dilution of 1: 3000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
