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Anti-BRCA2 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | BRCA2 rabbit polyclonal antibody |
Gene Name: | Breast cancer type 2 susceptibility protein |
Synonyms: | Brca2, BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11, Breast cancer 2, DNA repair associated, breast cancer 2, Early onset, BRCA2 DNA repair associated |
Immunogen: | Recombinant protein corresponding to Mouse BRCA2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Uniprot ID: | P97929, O35923 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1:1500-1:3000 | brain, hippocampus |
Background
BRCA2, also named as FACD and FANCD1, is involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. May participate in S phase checkpoint activation.
Images
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Immunohistochemistry of paraffin embedded mouse hippocampus using BRCA2 (GB111138) at dilution of 1:2200 (400x lens) |
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Immunohistochemistry of paraffin embedded rat hippocampus using BRCA2 (GB111138) at dilution of 1:1100 (400x lens) |
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Immunofluorescence of paraffin embedded mouse brain using BRCA2 (GB111138) at dilution of 1:2200 (400x lens) |
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Immunofluorescence of paraffin embedded rat brain using BRCA2 (GB111138) at dilution of 1:2200 (400x lens) |
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Immunofluorescence of paraffin embedded rat hippocampus using BRCA2 (GB111138) at dilution of 1:2200 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
