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| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Bcl10 rabbit polyclonal antibody |
Gene Name: | B-cell lymphoma/leukemia 10 |
Synonyms: | Bcl10, BCL10, CARMEN, CIPER, CLAP, c-E10, mE10, IMD37, B-cell CLL/lymphoma 10, B cell CLL/lymphoma 10, immune signaling adaptor, BCL10 immune signaling adaptor |
Immunogen: | Recombinant protein corresponding to Mouse Bcl10 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Uniprot ID: | Q9Z0H7, Q9QYN5 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 250-1: 2500 | brain, colon, lung, small intestine, spleen |
Background
B-cell lymphoma/leukemia 10 contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and pro-caspase-9 maturation and to activate NF-kappaB via NIK and IKK. The protein may be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. It is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with the paracaspase MALT1.
Images
 | Immunohistochemistry of paraffin embedded mouse colon using Bcl-10 (GB11771) at dilution of 1:2500 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse spleen using Bcl-10 (GB11771) at dilution of 1:2500 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat brain using Bcl-10 (GB11771) at dilution of 1:2500 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat spleen using Bcl-10 (GB11771) at dilution of 1:2500 (400x lens) |
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Immunofluorescence of paraffin embedded mouse colon using Bcl-10 (GB11771) at dilution of 1:500 (400x lens) |
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Immunofluorescence of paraffin embedded mouse lung using Bcl-10 (GB11771) at dilution of 1:500 (400x lens) |
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Immunofluorescence of paraffin embedded rat small intestine using Bcl-10 (GB11771) at dilution of 1:500 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
